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    Hydroquinone / Tretinoin / Azelaic Acid / Hydrocortisone Cream compound texture
    Rx OnlyConsult RequiredSun Sensitivity

    Aesthetic Dermatology

    Hydroquinone / Tretinoin / Azelaic Acid / Hydrocortisone Cream

    Kligman's triple with azelaic acid added, for prescribers who want a fourth pathway during the hydroquinone cycle.

    Commonly prescribed formelasmadark spotshyperpigmentation

    What’s in it

    Available asCream

    Strengths are set by your prescriber. The ingredients above are the starting point.

    Call 424-228-1049Bring this to my provider

    Prescriber? Copy the Rx text · ePrescribe via SiPrescribe

    • Reviewed by a pharmacist, made for you
    • Ships anywhere in California · fees quoted
    • HSA / FSA eligible

    We quote the price before we fill · cash-pay · HSA/FSA eligible · 424-228-1049

    About This Formulation

    What this formulation is.

    Hydroquinone / Tretinoin / Azelaic Acid / Hydrocortisone Cream is a cream compounded by our pharmacists to your prescriber's order. It combines Hydroquinone, Tretinoin, Azelaic Acid and Hydrocortisone. Prescribers commonly use it for melasma, dark spots and hyperpigmentation. Your prescriber sets the strength of each ingredient, the base and the directions, with your skin type and treatment history in mind. Because it is made for you at our licensed pharmacy, your prescriber can adjust the formula over time.

    Custom strength

    Your prescriber sets the strength of each ingredient, as a percentage of the finished preparation, rather than choosing from fixed commercial strengths.

    Combination formula

    4 active ingredients in a single cream, rather than separate products. Our pharmacists check that the ingredients are compatible before it is made.

    Allergen-conscious bases

    We can leave out dyes, fragrance, parabens or gluten where the formula allows. Tell your prescriber or call us about any sensitivities.

    Your Compound Includes

    What comes with every prescription.

    Pharmacist review

    Every prescription is checked by a pharmacist for interactions, dosing and formulation compatibility before it is made.

    USP-grade compounding

    Prepared in our Los Angeles pharmacy to national compounding standards, with checks at every step.

    Shipping or pickup

    Shipped across California in plain, temperature-controlled packaging, or picked up on Pico Blvd.

    A pharmacist afterwards

    Call with a question after it arrives and you reach the pharmacist who prepared it.

    The Ingredients

    What's in Hydroquinone / Tretinoin / Azelaic Acid / Hydrocortisone Cream.

    Hydroquinone texture

    Hydroquinone

    melasma, PIH

    Tretinoin texture

    Tretinoin

    photoaging, acne

    Azelaic Acid texture

    Azelaic Acid

    rosacea, acne

    Hydrocortisone texture

    Hydrocortisone

    short-course inflammation/itch

    Hydroquinoneprimary

    In this formula: per prescriber

    Depigmenting agent · Range: 4%–12%

    Tretinoinprimary

    In this formula: per prescriber

    Retinoid · Range: 0.01%–0.1%

    Azelaic Acidsupport

    In this formula: per prescriber

    Dicarboxylic acid · Range: 10%–20%

    Hydrocortisonesupport

    In this formula: per prescriber

    Topical corticosteroid · Range: 0.5%–2.5%

    From prescription to your door.

    Your provider writes it, our pharmacists make it, and it ships or waits for pickup.

    1

    Talk to your provider

    Show this page to your physician, dermatologist or NP. They write the prescription.

    2

    The Rx reaches us

    Your provider ePrescribes, faxes or calls it in to Generation Pharmacy.

    3

    We compound it

    Prepared by our pharmacists with USP-grade ingredients. Most orders are ready in one to two days.

    4

    Delivered or picked up

    Shipped to your door, or waiting at the West LA pharmacy.

    Call 424-228-1049

    Available Forms

    Your prescriber selects the delivery form best suited to your needs.

    Cream

    Base Vehicle Options

    The base affects absorption, feel and tolerability. Your provider chooses the right one.

    cream

    For Providers

    Quick Rx Template

    Customize strength and vehicle as clinically indicated.

    Safety Considerations

    cycle use
    irritation/ochronosis risk
    strict sun protection
    irritation
    photosensitivity
    avoid in pregnancy
    mild stinging
    atrophy risk with prolonged use

    Related formulations

    View all Aesthetic Dermatology →
    Hyperpigmentation

    Hydroquinone / Tretinoin / Niacinamide Cream

    Clinician-cycled HQ program for stubborn melasma and PIH.

    View formulation     Hyperpigmentation

    Tranexamic Acid Capsule

    Oral adjunct for stubborn melasma—reduces pigment signaling systemically.

    View formulation     Hyperpigmentation

    Azelaic Acid / Tranexamic Acid / Niacinamide Cream

    High-strength azelaic acid with tranexamic acid for melasma and dark spots when hydroquinone is not wanted.

    View formulation
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    Please note: Compounded medications require a prescription from a licensed prescriber for an individual patient. Compounded medications are not FDA-approved. The FDA does not review them for safety, effectiveness or quality. A compounded medication is not the same as, or a generic version of, any FDA-approved drug. This page is general information, not medical advice. Your prescriber decides whether a treatment is right for you and sets the final ingredients, strength and dosage form.

    Questions

    Before you bring this to your provider

    CallShow providerRx text