Melasma & Dark Spot Formulas
Formulas for melasma and dark spots, with or without hydroquinone. Prescription only.
Available Formulations
4 compounds available — each one compounded to the strength and vehicle your prescriber specifies.
Hydroquinone + Tretinoin Cream (Rx)
Generation PharmacyHydroquinone-based cream for melasma and dark spots, compounded to the prescriber's order. Dispensed in an airless pump.
Key Ingredients
Prescribed for
Tranexamic Acid + Azelaic Acid Cream (Rx)
Generation PharmacyHydroquinone-free formula for melasma and dark spots, compounded to the prescriber's order.
Key Ingredients
Prescribed for
Tranexamic Acid Capsules (Rx)
Generation PharmacyOral tranexamic acid, compounded to the prescriber's order (off-label for melasma).
Key Ingredients
Prescribed for
Tranexamic Acid + Vitamin C + Glutathione Capsules (Rx)
Generation PharmacyCapsule combining tranexamic acid, vitamin C and glutathione, compounded to the prescriber's order.
Key Ingredients
Prescribed for
How These Ingredients Work
Understanding what's in your formula — in plain language.
Hydroquinone
Turns down the skin's pigment-making process so dark patches fade over time.
⚠️ Irritation/dryness
Tranexamic Acid
Helps calm the signals that tell skin to overproduce pigment—especially in melasma.
⚠️ Oral TXA requires medical screening
Kojic Acid
Helps reduce excess pigment production and supports a brighter, more even tone.
⚠️ May be irritating in sensitive skin
Tretinoin
Speeds skin renewal and supports collagen—improves texture, pores, fine lines, and uneven tone.
⚠️ Dryness/peeling early
Glutathione
Antioxidant support sometimes used in brightening-focused regimens as an adjunct ingredient.
⚠️ Not a substitute for sunscreen/topical plans
Niacinamide
Strengthens the skin barrier and helps calm redness while supporting a more even tone.
Safety & Expectations
Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. All formulations require a valid prescription and are prepared in our state-licensed California pharmacy.
Questions About a Skin Prescription?
Share these formulas with your prescriber. Their office can call our pharmacists with questions about strengths and bases.