Bioidentical estrogen
Estradiol
White to off-white cream or troche
Typical Strength
per prescriber
Formulations
3 compounds
Formula
C₁₈H₂₄O₂
Mol. Weight
272.38 g/mol
How It Works
Mechanism of action
The primary circulating bioidentical estrogen. Binds estrogen receptors to maintain bone density, vaginal and skin tissue, and vasomotor stability. Central to BHRT; compounded to exact doses and delivery routes per lab-guided prescribing.
What compounding can change
When Estradiol is compounded for one patient, your prescriber can choose the concentration, combine it with other ingredients, and pick the base. Commercial products come in fixed strengths and bases.
Safety Considerations
Available In
Formulations with Estradiol
Bi-Est (Estradiol / Estriol) Cream or Capsule
Classic Bi-Est combination for comprehensive menopausal support.
Estradiol Cream or Gel
Single-estrogen transdermal estradiol at exact prescriber-set doses — including patch-equivalent conversions during shortages.
Estradiol Vaginal Cream or Insert
Low-dose local estradiol for genitourinary syndrome of menopause (clinician-led).
Commonly paired with
These ingredients frequently appear alongside Estradiol in our formulations.
Please note: Compounded medications require a prescription from a licensed prescriber for an individual patient. Compounded medications are not FDA-approved. The FDA does not review them for safety, effectiveness or quality. A compounded medication is not the same as, or a generic version of, any FDA-approved drug. This page is general information, not medical advice. Your prescriber decides whether a treatment is right for you and sets the final ingredients, strength and dosage form.