Bioidentical estrogen
Estriol
White to off-white cream
Typical Strength
0.1%–0.3%
Formulations
2 compounds
Formula
C₁₈H₂₄O₃
Mol. Weight
288.38 g/mol
How It Works
Mechanism of action
Weak estrogen receptor agonist that stimulates dermal collagen, glycosaminoglycans, and skin thickness without significant systemic estrogenic effects at topical doses.
What compounding can change
When Estriol is compounded for one patient, your prescriber can choose the concentration, combine it with other ingredients, and pick the base. Commercial products come in fixed strengths and bases.
Safety Considerations
Available In
Formulations with Estriol
Bi-Est (Estradiol / Estriol) Cream or Capsule
Classic Bi-Est combination for comprehensive menopausal support.
Estriol Vaginal Cream or Insert
Localized estriol support for vaginal comfort (clinician-led).
Commonly paired with
These ingredients frequently appear alongside Estriol in our formulations.
Please note: Compounded medications require a prescription from a licensed prescriber for an individual patient. Compounded medications are not FDA-approved. The FDA does not review them for safety, effectiveness or quality. A compounded medication is not the same as, or a generic version of, any FDA-approved drug. This page is general information, not medical advice. Your prescriber decides whether a treatment is right for you and sets the final ingredients, strength and dosage form.