PDE5 inhibitor
Sildenafil
White to off-white troche or cream
Typical Strength
10–100 mg/unit (oral) | 2%–5% (topical)
Formulations
5 compounds
Formula
C₂₂H₃₀N₆O₄S
Mol. Weight
474.58 g/mol
How It Works
Mechanism of action
Selective PDE5 inhibitor. Prevents degradation of cGMP in corpus cavernosum smooth muscle, enhancing nitric oxide–mediated vasodilation and penile erection in response to sexual stimulation.
What compounding can change
When Sildenafil is compounded for one patient, your prescriber can choose the concentration, combine it with other ingredients, and pick the base. Commercial products come in fixed strengths and bases.
Safety Considerations
Available In
Formulations with Sildenafil
Sildenafil Dissolvable
Fast-dissolve ED option with clinician screening and counseling.
Sildenafil / Tadalafil / Apomorphine Dissolvable
Three ED mechanisms in one dissolvable troche, strengths set by the prescriber.
Sildenafil / Tadalafil Dissolvable
Dual-PDE5 troche pairing on-demand and longer-window coverage in one unit (clinician-screened).
Sildenafil / Oxytocin Dissolvable
Sildenafil with oxytocin in a single ODT, compounded to the prescriber's order.
Sildenafil / Tadalafil / Apomorphine / Oxytocin Dissolvable
Four-mechanism sublingual for prescribers who combine vascular, dopaminergic and oxytocin support.
Commonly paired with
These ingredients frequently appear alongside Sildenafil in our formulations.
Please note: Compounded medications require a prescription from a licensed prescriber for an individual patient. Compounded medications are not FDA-approved. The FDA does not review them for safety, effectiveness or quality. A compounded medication is not the same as, or a generic version of, any FDA-approved drug. This page is general information, not medical advice. Your prescriber decides whether a treatment is right for you and sets the final ingredients, strength and dosage form.