Antiandrogen
Spironolactone
Smooth white cream with soft matte finish
Typical Strength
topical 2%–5% | oral per prescriber
Formulations
2 compounds
Formula
C₂₄H₃₂O₄S
Mol. Weight
416.57 g/mol
How It Works
Mechanism of action
Competitive aldosterone antagonist with potent anti-androgen properties. Topically, blocks dihydrotestosterone binding at the follicular androgen receptor, reducing sebum production without systemic effects.
What compounding can change
When Spironolactone is compounded for one patient, your prescriber can choose the concentration, combine it with other ingredients, and pick the base. Commercial products come in fixed strengths and bases.
Safety Considerations
Available In
Formulations with Spironolactone
Spironolactone / Niacinamide Cream
Hormonal acne support without oral therapy (clinician-led).
Minoxidil / Spironolactone Capsule
Low-dose oral minoxidil with spironolactone for female pattern hair loss, dosed by the prescriber.
Commonly paired with
These ingredients frequently appear alongside Spironolactone in our formulations.
Please note: Compounded medications require a prescription from a licensed prescriber for an individual patient. Compounded medications are not FDA-approved. The FDA does not review them for safety, effectiveness or quality. A compounded medication is not the same as, or a generic version of, any FDA-approved drug. This page is general information, not medical advice. Your prescriber decides whether a treatment is right for you and sets the final ingredients, strength and dosage form.